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Ein Lehrer wehrt sich! Herr H. Frau Ruth hat die Hoffnung aufgegeben. Psychiatrie und der sanfte Mord. Frau E. Frau A. Der Staatsanwalt wartet bis zum Tod. Die Psychiatrie nimmt jeden gerne. Frau U. Ein Psychiatriefall. Frau M. Ein Russischer Fahrlehrer wurde bei einem Unfall schlimm verletzt, kein Arzt wollte helfen.

Herr X. Frau W. Deswegen wird sie politisch verfolgt! Herr W. Am Ende der Rechtstaatlichkeit. Frau Y. Udo P. Ausschnitte aus mehreren Telefonaten. Frau B. Jugendamt, DDR und Elternmord. Wir haben die Kraft!!! Frau V. Wahrscheinlich Ja! Herr Y. Anstatt so genanntes. Jugendamt Attentat? Das Auto war gestohlen. Forensik: EIne Mitarbeiterin, die in der Psychiatrie gearbeitet hat, berichtet von ungesunden Methoden und Repressalien.

Frau Z. Es lauert keine Gesundung, sondern die Vergiftung der Gesundheit. Kampfsportlehrer Zurmwehme und Kollegen aus dem Milieu:. Bestellung: oder Mexiko gilt als sicherer als Deutschland:. Frau G. Frau Auerswald vermutet, dass es der gesuchte Walter Parker ist. Frau S. Brutale Polizeibeamte wollten sie nackt aus der Wohnung zerren. Das war anscheinend so organisiert worden. Polizeigewalt war ein Mittel dazu.

Herr G. Er kann kaum noch gehen und telefonieren. Seine Kraft ist am Ende. Frau J.. Ein Polizeibeamter hat bei mir das Haus in Brand gesteckt! Er hatte sich unbeliebt gemacht, als er einen Polizeibeamten hinter Gitter bringen wollte. Haus St. Hubertus, Alten- und Pflegeheim GmbH. Fon: Psychiatriefall: Todesfall Holger Z.. Frau X. Psychiatriefall: Kinder haben es besonders schwer, wenn Giftstoffe als Medikamente gehandelt werden:.

Es war schrecklich! Frau H. Vergiftete Zecken als Mordwerkzeug von Kindern ausgesetzt. Tierhalterin wurde brutal von der Polizei festgenommen und vom Exmann mit Mord bedroht. Frau R. Schaden etwa Psychiatriefall: Frau C.

Frau K. Herr I. Giftige Gase waren in den Arbeitsplatz gelangt und Herr I. Er hat Millionen-Anspruch. Die Mutter wurde mit der Pistole bedroht. Pornografische Bilder auf dem PC des Mannes. Pflegeheime als Folterlager! Es handelt sich um eigene Erfahrungen mit der Organisation.

Frau L. Jetzt kam es zu vielen Klagen bei Gericht. Neuer Fall: Frau M Es geht um Leben oder Sterben. Die Gefangenen wurden gefesselt und mit menschenlebenverachtenden Praktiken traktiert. Polizeiliches Bombenkommando gegen Zeugenaussage. Drogen sind ihnen wichtiger! Zweck solcher Repressalien ist, den einzigen wichtigen Zeugen zum Schweigen zu bringen. Kinderklau: Frau E. Neuer Fall: Frau Eger wurde das Kind weggenommen. Hamburger Polizei folterte Mutter in der eigenen Wohnung.

Neuer Fall: Polizeifolter im wahrsten Sinne des Wortes. Hier geht es um ein en Vermieter, der Mitglied im Rotay Club ist. Das wollte sich der Vermieter nicht gefallen lassen. Brutale Intrigen nahmen ihren Lauf. Die Polizei als Folterverbrecher im Auftrag? Polizei schlug auf eine Frau ein, weil sie telefonieren wollte! Weil eine junge Frau telefonieren wollte, wurde sie polizeilich misshandelt.

Der Griff zum Handy war der Polizei zu viel. Nazi-Experimente im Visier. Frau Conta beschreibt unfassbare Dinge im Krankenhaus. Neuer Fall: Fau C. Sie hat die Geschehnisse gut beschrieben. Polizei im Saarland mit automatischen Waffen unterwegs!

Mit Maschinengewehren kamen Sie und entsorgten daher die ganze Familie in die Psychiatrie. Sie sind jetzt schon alle tot. Die Polizei im Saarland will an sein Leben. Sein Leben ist nur noch kurz. Auch Bundeskanzlerin Angela Merkel meldet sich zu Wort. Ein Anwalt verlor seine Zulassung, mehrere unschuldige mussten in Haft. Herr und Frau X. Maschinengewehre waren im Einsatz! Herr Wagner wurde bei den Demonstrationen Stuttgart 21 schwer verletzt. Marguerite Burnat-Provins. Anna Schuster. Ina Reck.

Here Erdis. Maria Homscheid. Anna Hilaria von Preuss. Adelheid Schneller. Marthe Fiel. Wilma Vermaat. Hulda Paul. Margarete Bruns. Anda Cantegrive. Franza Feilbogen. Magdeleine du Genestoux. Marie Louise Suttner. Marie Nervat. Ilse Hamel. Gretchen Barthelmes. Jeanne Pouquet. Gertrud Pfander. Alice Schalek. Free Territory of Trieste. Hanna O'Donell. Frieda Magnus-Unzer. Sant Antoni de Portmany. Helene Aeckerle.

Emma Cramer-Crummenerl. Johanna Madeleine Elout. Marie Liebermann. Ea von Allesch. Suzanna Maria van Woensel Kooy. Beatrice Zade. Louise Chardon. Elisabeth Bauck. Henriette Brey. Margarete Beutler. Agnes Wurmb. Hedda Wagner. Jean Rosmer. Sophie Arnim. Lilly Braumann-Honsell. Marie de Rohan-Chabot. Helene Granitsch. Marion Gilbert. Rose Austerlitz. Max du Veuzit.

Annemarie von Auerswald. Hungary Germany. Lya Berger. Ada Battke. Lina Roth. Willemien Brom-Struick. Klara Philipp. Clara Harnack. Dora von Bodenhausen-Degener. Lisa Baumfeld. Else Krafft. Dora Eleonore Behrend. Paula Buber. Yvonne Loisel. Rose Mangoldt. Henriette von Schrott-Pelzel. Leonore Pany. Maria Batzer. Anna Schapire-Neurath. Jean de Belcayre. Minna Burgarth.

Else Jerusalem. Hanna von Pestalozza. Therese Rie. Ingeborg Andresen. Christine Touaillon. Marie de La Hire. Marthe Bertheaume. Else Croner. Elsa Sophia von Kamphoevener. Elise Haas. Franziska Rademaker. Frigga Brockdorff-Noder.

Adelheid Petersen. Maria Waser. Bess Brenck-Kalischer. Elsbeth Borchart. Helene Johanna Zeller. Hela Sander-Weiss. Bettina Holzapfel-Gomperz. Hermine Cloeter. Rosa Maria Barth. Marie Charlotte Siedentopf. Hildur Dixelius. Sophie Jacot des Combes. Switzerland German Reich. Leonore Niessen-Deiters. Cornelia Serrurier. Ilse Dernburg. Tine Brinkgreve-Wicherink. Wilma Vukelich. Else Morstatt. Julie Kniese.

Anna Sutorius. Margarete Weinhandl. Elvira Mihelffy. Erika Spann. Neustift an der Lafnitz Oberwart. Anna Ilgenstein. Ina Jens. Marie Lahy-Hollebecque. Augusta von Oertzen. Anna Hofheinz-Gysin. Luise Beccard-Blensdorf. Mervyn Brian Kennicott. Irma Hartje-Leudesdorff. Margit Altai. Anna Siemsen. Anna Hubert van Beusekom. Frances Magnus von Hausen. Nine van der Schaaf. Fanny von Wilamowitz-Moellendorff.

Luise Bresslau-Hoff. Margarete Bruch. Hermine Maierheuser. Maria de Crisenoy. Maria Weinand. Martina Wied. Ida Frohnmeyer. Germany Switzerland. Marie-Louise Charran. Brigitte Adolphsen. Jeanne Nabert. Marie Jorns. Florentine Goswin-Benfer. Helene Goldbaum. Eleonore Kalkowska. Poland German Reich. Christine Holstein. Leontine von Winterfeld-Platen. Zuster Maria-Jozefa.

Christiane Aimery. Marta Lepp. Dorothee von Velsen. Agnes Millonig. Elisabeth Oehler-Heimerdinger. Hertha Koenig. Adele Elkan. Else von Hollander-Lossow. Marie Muthreich. Olga Essig. Villa Hammerstein. Margarete Windthorst. Zoe Droysen. Ramsau bei Berchtesgaden.

Gizella Dapsy. Lola Stein. Jean Alley. Anna Kayser. Josephine Schneider-Foerstl. Thea de Haas. Aline Aliberti. Johanna Herzfeldt. Ilona Unger. Jane Tatarin-Tarnheyden. Elisabeth Hillebrandt. Marianne Philips. Elisabeth Loofs. Jeanne Maxime-David. Berthe Bernage. Charlotte E. Hungary Romania. Esther Gretor. Alice Fliegel. Mara Heinze-Hoferichter. Gertraud Enderlein. Else Eberhard-Schobacher. Marta Sillaots. Thyde Monnier. Elisabeth Baumann-Schlachter. Liane von Gentzkow. Hedwig Anneler. Elisabeth Segelken.

Lindau am Harz. Helene Helming. Gizella Ambrus. Elisabeth Josephi. Clara Schulte. Louisa Paulin. Nora Kinsky. Sofia Fedorchenko. Russian Empire Soviet Union. Camille Mayran. Ania Teillard. Marta Karlweis-Wassermann.

Friedl Beutelrock. Germaine Acremant. Jenny Ritzhaupt. Magda Bergquist von Mirbach. Skara city parish. Lina Kromer. Margareta Diersch. Hedwig Weiss. Maria Mathi. Rose Woldstedt-Lauth. Katherine Butler Hathaway. Baltimore Salem. Magda Ferenczi. Erna Pinner. United Kingdom Germany. London Borough of Camden. Elsa Faber von Bockelmann. Gertrud Papendick. Miek Janssen. Fridel Koehne. Lily Schwenger-Cords. Alie Smeding. Brigitte von Rechenberg.

Martha Wertheimer. Ilona Stima. Caroline D. Else Schubert-Christaller. Cilette Ofaire. Margarete Zur Bentlage. Bertha Dudde. Else Rosenfeld. Kaethe Schulken. Maria Kahle. Emmy van Lokhorst. Lilly Ackermann. Mary Dorna. Margot Vos. Mary Lavater-Sloman. Margaretha Renes-Boldingh. Eugenie Fink. Gil Reicher. Sofie Schieker-Ebe. Else Sparwasser. Frida Schuhmacher. Gertrud von den Brincken. Agathe Lindner-Welk. Hanna Klose-Greger.

Amalie Halter-Zollinger. Gertrud Busch. Catherine Colomb. Jenny Humbert-Droz. Tatyana Vechorka. Soviet Union Russian Empire. Gerda Siemer. Holdine Stachel. Lola Landau. Germany Israel. Helene Haluschka. Helene Weyl. Polly Tieck. Senta Dinglreiter. Ilona K. Gertrud von Brockdorff. Fredensborg Municipality. Marguerite Verdat. Charlotte Woerner. Mela Spira. Yelena Bulgakova. Severa Dennstedt. Elisabet van Randenborgh.

Tamara Solonevich. Leni Behrendt. Lucienne Ercole. Lotte Meckauer. Irmgard Faber du Faur. Ilona Csengery. Marte Brill. Ilse Ringler-Kellner. Elfriede Schirrmacher. Gerda von Buttlar-Below. Paula Busch. Lisa Matthias. Germany Sweden. Elsa Margot Hinzelmann. Hertha Borchert. Erna Blaas. Kirchdorf an der Krems. Annelies Umlauf-Lamatsch. Hermsdorf Schloss Hermsdorf. Eva Rechel-Mertens. Lilly zu Rantzau. Emma Nagy. Maria Ferschl. Lucie Rauzier-Fontayne. Marie Colmont.

Eleonore Lorenz. Susanne Leonhard. Elisabeth Gerter. Gabrielle Baron. Irma Reismann. Tamara Ramsay. Germany Russian Empire. Anna Mosolf. Maria Jacoba Delbaere-Prins. Alice Spies-Neufert. Gertrud Liska Drechsler. Marcelle de Jouvenel. Alma Holgersen. Ilse Leutz. Rosie Newman. Marie-Louise Grobert. Magda Aranyossi. Edith Werkendam. Clara Asscher-Pinkhof. Kingdom of the Netherlands Israel. Eugenia Martinet. Italy Kingdom of Italy. Yvonne Girault. Wally Eichhorn-Nelson. Ernstthal am Rennsteig. Emma Waiblinger.

Gerty Spies. Daniela Krein. Ise Gropius. Anni Kraus. Marcelle Drutel. Elisabeth Walter. Anna Wambrechtsamer. Austria Kingdom of Yugoslavia Austria-Hungary. Germaine Verdat. Anni Geiger-Hof. Ada Kretzer-Hartl. Anke Servaes. Martha Saalfeld. Gertrud Meyer. Lily Pincus. Lally Horstmann. Dora Puelma. Marie Harder. Hedwig Katscher. Margarete Wittber. Elisabeth Emundts-Draeger. Colette Vivier. Gabriele von Sazenhofen. Babette Gross.

Marianne Angern. Hertha Vogel-Voll. Rachel Minc. Clarisse Francillon. Ida Ospelt-Amann. Ruth von Ostau. Paula Schlier. Lida Durdikova. Ilse Langner. Maria Felchlin. Berta Schmidt-Eller. Elisabeth de Meijier. Meester Cornelis. Marguerite Bourcet. Charlotte Stein Pick. Juliana von Stockhausen. Elisabeth Schnack. Helga Menzel-Tettenborn.

Mary Cressac. La Rochefoucauld. Elisabeth Fischer-Markgraff. Margarete Benda. Colette d'Hollosy. Marcelle Sauvageot. Eva Raedt-de Canter. Dorothea Hollatz. Maria Veronika Rubatscher. Gerhart Ellert. Hildegard Plievier. Bad Oberdorf. Ida Bobula. Ida Bohatta. Grete Scheuer. Juliette Milette. Erika Lichte. Alice Ekert-Rotholz. Johanna Haarer. Jo Landheer. Diane Whitley. Juliette Aleth. Anne-Marie Poncet-Denis. Elissa Ambrose. Maria Langner. Julia Menz. Lina Staab. Marie-Jeanne Durry. Alice Herdan-Zuckmayer.

Rose Gronon. Zsuzsa Thury. Kathrine Aurell. Ditha Holesch. Gerda von Kries. Alice Piguet. Rut Bahlsen. France German Empire. Tine Rabhooy. Illa Andreae. Albertine Deletaille. Ida Kiss. Elisabeth Heimpel. Jeanne Laurent. Hanna Stephan. Lydie Sarazin-Levassor. Julia Tulkens. Anne-Mary Gaudin de Lagrange. Marguerite Michaud. Julianna Zsigray.

Germaine Pelletan. Jeanne Loviton. French lawyer, business woman, publisher and courtesan, better known by her pen name Jean Voilier. Charlotte Temming. Odette Sorensen. Emmy Herzog. Mia Seeger. Erna von Ostau. Lene Bertelsmann.

Elina Vaara. Orsola Nemi. Annalise Wagner. Luise Bachmann. Gaude Roza. Paula Oravecz. Victoria Wolf. Annie Schmidt-Endres. Marcelle Ferry. Natha Caputo. Lilika Naku. Athens Livadeia. Luisa Mercedes Levinson. Juliane Kay.

Anneliese Hager. Arlette de Pitray. Hilde Rubinstein. Martha Weber. Claude Renaudy. Henriette Haill. Liane Holst. Benedicta Maria Kempner. Geislingen an der Steige. Betty Wehrli-Knobel. Hildegunde Fritzi Anders. Ina Roberts. Wolkersdorf im Weinviertel. Ellen Soeding. Marit Laurin. Ingeborg Engelhardt. Jutta Hecker. Ines Widmann. Meta Scheele. Ursula Mangoldt. Ida Urr. Klara Blum. Barbara Levinger. Bee Juker. Michel Davet.

Brigitte von Arnim. Gertrud Heizmann. Maria Fagyas. Hungary United States of America. Lotte Denkhaus. Ursula Wiese. Hedwig Dorosz. Annik Saxegaard. Fredericka Martin. American writer, photographer, historian, and chief nurse and administrator of the American medical volunteers who served during the Spanish Civil War Ada von Boeselager. Pita Grilk. Eva van Hoboken. Germany Kingdom of the Netherlands. Olga Brand. Maria Graber-Meinen. Weissenburg im Simmental. Erlenbach im Simmental. Lotte Betke.

Anna Fazekas. Hildegard Cornelsen. Marina Thudichum. Constancia de la Mora. Aili Konttinen. Claudine Chonez. Ferny Besson. Marcelle Lerme-Walter. Vera Ketlinskaya. Lea Grosse. Germany Poland. Rosalia Wenger. Ruth Rewald. Auschwitz II-Birkenau concentration camp. Maria van der Steen. Annie de Moor-Ringnalda. Elisabeth Freundlich. Susanne Ehmcke. Maria Prat. Lydia Kath. Wierzchowo, Drawsko County. Ljubov Voronkova.

Franziska Bilek. Karin Bucha. Gertrude Pape. Lu Jingqing. Erika de Bary. Constance Lindsay Taylor. Erica Lillegg. Herta Zerna.

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Charles N. Thomas W. Ruth E. Essie M. John W. She began her career as a first-grade teacher in , and served as a teacher and principal at various elementary schools in the city, retiring in She lived with her two sisters, who were also teachers, and traveled the world with them in the summers, according to her niece. Scott MacKenzie Jr. Department of Agriculture; Nov. He worked for the switch-gear division of General Electric during the s, until joining New York Life in the s. He maintained his insurance license and never fully retired.

During the Bicentennial, he and his wife participated in events at Valley Forge National Historical Park in colonial costumes she had made. Alphonsus R. He had taught veterinary ethics at Penn, and law at Temple University for 30 years. And he served on the board of the town library. In he was part of the small group attending the 60th reunion of Wharton graduates.

Herbert C. Gross Jr. David R. Richard A. After working several years in a family pharmaceutical business, he founded Jenard in Yeadon, Pa. Kaskey Memorial Garden, in honor of his son. Herbert L. Laurence A. His brother, Preston, became his partner in ; during the next dozen years, they purchased hotels in New York, New Jersey, and Florida.

Intrigued by the underlying real-estate assets of the company, the brothers began demolishing old Loews movie theaters in New York and building modern apartment buildings and hotels on their sites. In he acquired almost 25 percent shareholding of CBS, where he became acting chief executive until its acquisition by Westinghouse Electric Corporation in He retired as chief executive officer of Loews in , when one of his sons, James S.

Among his grandchildren are Alexander H. Gerald Y. He was a senior vice president and director of Saks Fifth Avenue and a vice president and director of Gimbel Brothers. As senior vice president for real estate, he was in charge of expansion and development for the Batus retail division former parent company of Saks Fifth Avenue and Gimbel Brothers , he played an integral role in the complex planning and development of the former Swiss Bank Tower behind Saks flagship store.

Following his retirement in , he was a real-estate consultant for the Batus, vice-chair of the Harlan Company, and president and chair of the Peruvian Avenue Corporation of Palm Beach, Fla. His son is Michael S. Barclay M. Sumner B. Charles E. Frank J. Bowden Jr. He taught at Wharton and began his career as an attorney with his father in Philadelphia, before joining the former Delaware Valley Council, now the Penjerdel Council, a tri-state regional and economic planning agency that was established in As council secretary, he served on many civic committees and published a resource guide for information on the Delaware Valley.

In , he became the executive director of Associated Petroleum and was a spokesman and lobbyist for the petroleum industry for over 20 years, until his retirement in the s. He then worked as a consultant to oil companies. The grandson of a man who had operated a tugboat on the Delaware River in the s, he had been involved in a project to dredge a channel in the Delaware River to improve shipping.

He was an active participant in several community organizations and was the former director of the Radnor, Ithan, and St. Jerome D. Louis R. He taught at the University, where an award for teaching was named after him. Lloyd A. Thomas E. Culbert G. Rutenber Lectureship was established in his honor in During , he served as president of the then American Baptist Convention. He was chair of the Council on Christian Social Progress and a member of the advisory committee for theological education, among many other denominational positions.

An outspoken advocate for Christian social activism and pacifism, during the s he became active in the civil-rights movement, marching in the South and participating in the March on Washington with Dr. Martin Luther King. Rutenber invited Dr. King to speak twice at national gatherings for predominantly white American Baptists. While a pastor at Linden Baptist Church during the s, Dr.

Rutenber opened a dialogue with those in the socialist movement, learning about their concerns for justice and inviting them to attend his church. He was later an emissary for the American Baptist Churches to Communist countries, seeking to create a dialogue between Christianity and communism. Rutenber was a visiting professor and lecturer at numerous colleges and universities throughout the U.

He also wrote Peace-keeping or Peace-making, a pamphlet for the Society of Friends. Edith M. Frances W. McWilliams Jr. During the Second World War he served as a communications specialist on a U. Navy destroyer in the Pacific until Owsley Jr. Wallace L. Everett J. Hazel V. Albert G. Paul R. She worked as a nurse at Bryn Mawr Hospital and then privately.

Following her retirement in , she served two terms on the school board of Upper Merion, during which she initiated a college-scholarship program for students. She was a nurse at a U. Roy M. An occupational therapist, she had been the director of the Delaware Curative Workshop in Wilmington.

At Penn she was a member of Kappa Alpha Theta sorority. Joseph R. His parents operated a small boarding house in Wildwood, N. His interest in linguistics developed when his family moved to South Philadelphia and he heard Italian and Yiddish spoken in his neighborhood. Applegate began his career at MIT in , where he served as a linguist on the staff of the mechanical-translation project of the Research Laboratory of Electronics there, a loosely collaborative program between MIT and Penn.

In he was appointed one of the first African-American faculty members at MIT, and became director of its new language laboratory in During his tenure he conducted research on language acquisition that described the phonology of a dialect spoken by children in a black family in Cambridge. The study, published in Word in , is frequently cited by linguists as a classic of its kind.

At Howard he was associate professor of linguistics from to , director of the African studies and research program , and professor of African studies from until his retirement in He led the successful effort to establish a Ph.

James C. David N. Julius Arch Colbrunn Jr. James D. Edward N. Benjamin P. Paul G. In , he was part of the Duke Desert Expedition to Algeria, where the team discovered that a camel does not store water in its hump but saves water by allowing its body temperatures to rise and conserve nitrogen by recycling it, which led to his Ph.

His travels in Lapland in investigated medical physiology in reindeer. At Cornell his research into the feeding physiology of ruminants and pigs discovered the source of the time-to-stop eating signal, causing him to comment that if humans ate like pigs, we would seldom overeat. Although retired from teaching, Dr. Houpt maintained an active research laboratory at Cornell until his death.

Laurence M. William R. Samuel B. Robert L. Alfred S. Dickran Y. He had worked for Westinghouse Electric Corporation. John M. Richard H. Leonard H. During the late s, Dr. Perlish became associated with the Institutes for the Achievement of Human Potential in Wyndmoor, leading to his doctorate in early childhood education and pediatric neurophysiology at the University. He served on the board of the Institutes for the Achievement of Human Potential.

And he was president of the World Organization for Human Potential. Milton H. Richard G. Martin R. Chester M. John E. He handled the legal planning for construction and rehabilitation projects of its four bridges and the Patco High-Speed line for nearly 25 years. And he had earlier served as solicitor of Delaware township in New Jersey from to Louis C.

Richard D. George B. Lemmon Jr. Murray S. John C. Barba Jr. Irene P. Karl L. Garner Jr. Frank R. Augustine, Fla. Jack E. Douglas G. Lovell Jr. At Penn she was a member of Kappa Delta sorority. Joseph N. Active in various civic and community organizations, he specialized in helping college students obtain financial aid.

He had served for the diplomatic service at the U. Robert F. Guido A. Stephen M. William M. Michael L. He retired as a human-resources consultant in During the Korean War, he served as a lieutenant in the U. Army, retiring as a captain in His brother is James B. Nancy S. Herbert N. Lars S. Following retirement, he volunteered at the Naples Community Hospital for 12 years.

Allan H. Joseph T. On the faculty there for 35 years, he served as department chair from to Rosen published many articles on number theory and co-wrote three textbooks on calculus and probability. For over 50 years he played double bass in the Swarthmore College Orchestra; its autumn concert last year was dedicated to his memory. And he was on the board of Orchestra , an ensemble that specializes in contemporary classical music. Warren F. Dante Giuliani Jr. John B. Martin Jr.

George W. Martyn Jr. Robert D. He had worked for Derby Print and Copy. Richard B. During his tenure, he participated in a study of institutional investors that led to new disclosure rules. And more recently he was appointed to the national conference of commissioners on uniform state laws, serving from to William N. From the late s until , he worked as a design engineer and systems analyst engineer at the Philadelphia Navy Base, General Electric Co.

He was also an engineering consultant with several other firms. Michael A. At Penn he was a member of Zeta Psi fraternity and later served on its Philadelphia board. Joseph C. He was a former president of the Houston Society of Financial Analysts, the former vice president and director of the Center for the Retarded, Inc. And he had been director of the Wharton Club of Houston. Jonathan A.

William A. Robert E. He had retired from Conrail, Inc. He had been employed at Lock Haven State College. She began her career as a psychiatric nurse at the old Institute of Pennsylvania Hospital in Philadelphia, then served as a school nurse at West Philadelphia High School. In she became the nurse for the newly opened University City High School.

During the Second World War, she obtained the rank of captain as a U. Her son is Jonathan L. James S. He established an undergraduate scholarship fund at Penn. One of his sons is Alexander D. Edward L. Barbara S. Bertram S. He had also worked as for the firm of Thomas Wood. In later years he became active in business and real estate development in southeastern North Carolina, where he also lived. Walter E. Daniel W. She established and operated a veterinary practice in Westport until , when she joined the faculty at Tufts.

A course she developed in human-animal interactions served as a model for veterinary schools across the country. As one of the leading scholars on the relationship between humans and animals, Dr. Lawrence its Distinguished Service Award. Active in numerous professional and civic organizations, she was also the former chair of the admissions committee for the Tufts veterinary school. Lillian P. Raymond H. James A. She worked as a nurse at Episcopal Hospital in Philadelphia, and then at the Hospital of the University of Pennsylvania.

In the s, she became a school nurse for the districts of Abington and then Council Rock, where she served as the health-services coordinator for 10 years, until her retirement in Massie E. Rosalie B. In recent years they also lost another case that challenged child-access laws.

Her husband is Alan N. Her son is Joel A. Jeffrey A. Judson I. Henry I. Karen L. Jodie L. Daniel E. Peter D. He began as an investigator in , and was promoted to research specialist in He was a lecturer in physics and supervisor of the undergraduate and graduate physics laboratories from to While at Penn, he co-edited several editions of the undergraduate laboratory manual. In he became supervisor of the laser physics laboratory at General Electric Aerospace now Lockheed Martin , where he worked until his retirement in Charles R.

Joseph S. Catherine T. His son is Jason M. Mary S. Rosalind S. Maurita F. Parthenia L. William P. Robert M. He began his career as counsel to the Judiciary Committee of the U. House of Representatives under a Ford Foundation grant. He then practiced law, first in Philadelphia and then in the Poconos, where he moved in During his year career, he worked in seven foreign countries and 20 states, and assisted American citizens in being released from foreign prisons. In he received an Outstanding Advocacy Award for cases he pursued through the appellate process.

He was also an instructor in federal income and gift taxation at California Western School of Law. George O. DeBolt Jr. He worked for the Hospital of the University of Pennsylvania. Luscombe Jr. Enzo U. David E. At Penn he was a member of Sigma Chi fraternity. Phillips Sr. Harry H. Snellenburg Jr. Gordon P. Buzby Jr. He sailed as an undergraduate at Penn, achieving All American status for three consecutive years. In addition to surgery, Dr. The buffering function is important given the adverse effect of both low and high retinoid levels on the growth and function of diverse organs.

Thirdly, random retinoid distribution may not satisfy tissues that need a large amount of retinoid for proper function such as the eye. MWS patients typically present with various combinations of eye, heart, lung and diaphragmatic defects. Of note, all of the 20 MWS patients reported in the literature to date had eye anomalies in the form of anophthalmia or microphthalmia, with heart malformations being the second most consistent feature.

The clinical spectrum associated with STRA6 mutations is extremely variable and no correlations between the nature of a STRA6 mutation and phenotypic severity have been found Chassaing, et al. The current study has shown that patients homozygous for the STRA6 p. GK mutation can develop an isolated eye phenotype pedigrees 1 and 2 or the more severe MWS pedigree 3 , raising the question of how the GK mutation produces an isolated eye malformation of variable severity in some patients but a multi-system disorder in others?

Several mechanisms are proposed. Firstly, one of the simplest explanations for the observed phenotypic differences may relate to the nature and location of the pathogenic STRA6 mutation and its impact on STRA6 function. STRA6 is highly enriched in the retinal pigment epithelium in the adult eye Bouillet, et al. Accordingly, even small deficiencies in vitamin A are sufficient to produce an ocular malformation.

Therefore, although the STRA6 mutation observed in the MCOPCB patients results in an eye defect, there may still be sufficient uptake of vitamin A for proper functioning of the non-ocular tissues, such as the heart and brain, which do not have as high a dependency on vitamin A. In contrast, the more severe MWS mutations may result in complete loss of STRA6 activity in all tissues, leading to the multi-system malformations which extend beyond eye defects.

Secondly, differences in the timing and tissue expression of the mutation may explain why some patients with STRA6 mutations have a phenotype restricted to the eye, but others present with multi-organ syndromes. Thirdly, a second as yet unidentified disease gene may contribute to the broad spectrum of symptoms associated with MWS, similar to the tri-allelic inheritance model proposed in Bardet-Biedl syndrome BBS Katsanis, et al.

However, Isken and colleagues demonstrated that knock-down of stra6 in zebrafish produced a MWS phenotype whereby STRA6 deficiency resulted in craniofacial and cardiac defects and microphthalmia Isken, et al. Although these observations need to be confirmed in germline mutants, they indicate that loss of STRA6 alone is sufficient to produce the MWS phenotype.

Finally, the STRA6 p. GK mutation may exhibit variable expressivity, which is not uncommon for MAC disease genes Zenteno, et al. Similar to BBS, the inter- and intra-familial clinical variability in MCOPCB could be explained, in part, by the presence of second-site mutations that serve as modifiers of expressivity Beales, et al. Recent work by Yeyati and colleagues has demonstrated that functional reduction of a second gene, HSP90 , in two zebrafish eye mutants significantly influenced the expressivity of the eye defect Yeyati, et al.

Therefore it is possible that unidentified modifier loci may contribute to the variable expression of STRA6 mutations. It is also possible that while genetic factors predispose to eye malformations, the interaction of environmental risk factors may contribute to the development of multiple congenital anomalies, such as those observed in MWS.

It is well established that vitamin A intake alone either insufficient or excessive can lead to severe developmental defects without any genetic contribution Wilson, et al. We identified a missense mutation STRA6 p. We have shown that substituting a highly conserved glycine at residue with a lysine essentially abolishes vitamin A uptake activity of STRA6, most likely due to mislocalisation of the mutant protein.

Inhibition of retinoid synthesis in a zebrafish disease model reproduced the MCOPCB phenotype suggesting that individuals homozygous for the GK allele are unable to attain the intracellular levels of vitamin A and retinoids required to support normal eye development during embryogenesis.

To our knowledge, this is the first report of STRA6 mutations associated with isolated eye malformations. Currently, diagnostic genetic testing of the STRA6 gene is standard for patients presenting with MWS but is not typically recommended for patients with non-syndromic eye anomalies.

We sincerely thank the participating families for the use of genetic samples and clinical information. We would also like to thank Dr. Supporting Information for this preprint is available from the Human Mutation editorial office upon request moc. National Center for Biotechnology Information , U.

Hum Mutat. Author manuscript; available in PMC Feb 7. Author information Copyright and License information Disclaimer. Copyright notice. The publisher's final edited version of this article is available at Hum Mutat. See other articles in PMC that cite the published article. Abstract Microphthalmia, anophthalmia and coloboma MAC are structural congenital eye malformations that cause a significant proportion of childhood visual impairments.

Introduction Microphthalmia, anophthalmia and coloboma MAC are related structural, congenital eye malformations which display a spectrum of severity and can occur in isolation or as part of a syndrome. Open in a separate window. Figure 1. Materials and Methods Patients The initial family pedigree 1 was referred to the clinical genetic service for genetic assessment by at least one of the authors.

Targeted sequence capture A customised NimbleGen sequence capture array was designed to specifically isolate the four candidate homozygous regions at 15q23— Live and permeabilised cell staining of wild type and mutant STRA6 For live cell staining, a Myc epitope was inserted into an extracellular loop of human STRA6 between residues and Pharmacological inhibition of retinoid synthesis in zebrafish Zebrafish embryos were used to model different levels of retinoic acid using citral dimethyl acetal, a precursor to the retinoic acid synthesis inhibitor citral Marsh-Armstrong, et al.

Figure 2. Table 2 Candidate loci identified by SNP homozygosity mapping. Mutation analysis A custom NimbleGen sequence capture array was designed to target the genomic loci of interest at 15q23— Figure 3. Table 3 Novel homozygous mutations at the 15q The genomic positions refer to build hg Identification of STRA6 p. GK in additional patients Subsequently, another child from an apparently unconnected consanguineous Irish Traveller family presented at clinic with eye malformations pedigree 2; Figure 1B.

Figure 4. Pharmacological inhibition of retinoic acid synthesis in zebrafish In vitro analyses demonstrated that the GK STRA6 mutant has a severely diminished ability to transport retinoids into cells. Figure 5. Discussion We report a study to determine the causative mutation for autosomal recessive non-syndromic colobomatous micro-anophthalmia MCOPCB in a large consanguineous pedigree from an ethnic minority Irish population.

Intra-familial phenotypic variability The affected family members in pedigree 1 are homozygous for the same missense mutation but there is considerable heterogeneity in the phenotype of their eye malformations. Matthew Wood syndrome or isolated eye defects STRA6 has previously been implicated in MWS, a multisystem disorder that includes microphthalmia and anophthalmia Chassaing, et al.

Supplementary Material SuppMat Click here to view. Acknowledgments We sincerely thank the participating families for the use of genetic samples and clinical information. Footnotes Supporting Information for this preprint is available from the Human Mutation editorial office upon request moc. References Adams J. Structure-activity and dose-response relationships in the neural and behavioral teratogenesis of retinoids. Neurotoxicol Teratol. PAX2 mutations in renal-coloboma syndrome: mutational hotspot and germline mosaicism.

Eur J Hum Genet. Am J Hum Genet. A locus for autosomal recessive congenital microphthalmia maps to chromosome 14q Transport and storage of vitamin A. Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein. Mech Dev. Eye anomalies: seasonal variation and maternal viral infections.

Modelling the polypeptide backbone with 'spare parts' from known protein structures. Protein Eng. Teratogen-induced, dietary and genetic models of congenital diaphragmatic hernia share a common mechanism of pathogenesis. Am J Pathol. Teratology of retinoids. Annu Rev Pharmacol Toxicol. Mutations in SOX2 cause anophthalmia. Nat Genet. Human microphthalmia associated with mutations in the retinal homeobox gene CHX Genetic counseling in cases of microphthalmos and anophthalmos. J Genet Hum.

Autosomal-recessive posterior microphthalmos is caused by mutations in PRSS56, a gene encoding a trypsin-like serine protease. Am J Med Genet A. PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects. Matthew-Wood syndrome is caused by truncating mutations in the retinol-binding protein receptor gene STRA6. X-linked clinical anophthalmos.

Localization of the gene to Xq27—Xq Ophthalmic Paediatr Genet. A genome-wide linkage scan in Tunisian families identifies a novel locus for non-syndromic posterior microphthalmia to chromosome 2q Hum Genet. Genetic factors in congenital diaphragmatic hernia. Regional variation in blindness in children due to microphthalmos, anophthalmos and coloboma.

Ophthalmic Epidemiol. Environmental risk factors in congenital malformations of the eye. Ann Trop Paediatr. Retinoic acid. A key molecule for eye and photoreceptor development. Invest Ophthalmol Vis Sci.

Cell Metab. Bilateral anophthalmia with septo-optic dysplasia. Oman J Ophthalmol. Triallelic inheritance in Bardet-Biedl syndrome, a Mendelian recessive disorder. A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A.

An essential ligand-binding domain in the membrane receptor for retinol-binding protein revealed by large-scale mutagenesis and a human polymorphism. J Biol Chem. Mapping the membrane topology and extracellular ligand binding domains of the retinol binding protein receptor. Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndrome.

Fast and accurate short read alignment with Burrows-Wheeler transform. Retinoic acid is necessary for development of the ventral retina in zebrafish. Genome Res. A locus for autosomal dominant colobomatous microphthalmia maps to chromosome 15q12—q National study of microphthalmia, anophthalmia, and coloboma MAC in Scotland: investigation of genetic aetiology.

J Med Genet. Teratogenicity of isotretinoin revisited: species variation and the role of all-trans-retinoic acid. J Am Acad Dermatol. Teratogenicity of Vitamin A and Retinoids. Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation.

Pathways of vitamin A delivery to the embryo: insights from a new tunable model of embryonic vitamin A deficiency. Heterozygous mutations of OTX2 cause severe ocular malformations. SOX2 anophthalmia syndrome. Novel mutation in sonic hedgehog in non-syndromic colobomatous microphthalmia. Vitamin A transport in human vitamin A toxicity. N Engl J Med. BBS8 is rarely mutated in a cohort of Bardet-Biedl syndrome families. J Hum Genet.

Congenital eye malformations in , consecutive births. Ann Genet. Alteration in catalytic properties of human CYP2D6 caused by substitution of glycine with arginine, lysine and glutamic acid. Drug Metab Pharmacokinet. Anophthalmia and microphthalmia. Orphanet J Rare Dis. Mutations in the human RAX homeobox gene in a patient with anophthalmia and sclerocornea. Hum Mol Genet. Two novel STRA6 mutations in a patient with anophthalmia and diaphragmatic eventration.

Membrane protein folding and stability: physical principles. Annu Rev Biophys Biomol Struct. Mol Vis. An analysis of the syndrome of malformations induced by maternal vitamin A deficiency. Effects of restoration of vitamin A at various times during gestation. Am J Anat. Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomalies.

Hsp90 selectively modulates phenotype in vertebrate development. PLoS Genet. Anophthalmia-esophageal atresia syndrome caused by an SOX2 gene deletion in monozygotic twin brothers with markedly discordant phenotypes. Function of vitamin A in vertebrate embryonic development. J Nutr. Support Center Support Center. External link. Please review our privacy policy. Right choroidal coloboma, left anophthalmia small cystic mass.

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